王艷，1982年生，籍貫北京，分子腫瘤學國家重點實驗室研究員，博士生導師。2009年畢業于北京大學，獲生物化學與分子生物學博士學位。博士畢業后，先后在山東大學醫學院任副教授，天津醫科大學和首都醫學大學任教授。2019年10月進入中國醫學醫學院腫瘤醫院任研究員。

腫瘤發生發展與轉移的表觀遺傳轉錄調控機制；腫瘤代謝微環境通過表觀遺傳重編程促癌的分子機理，主要研究生活方式、環境毒素和藥物治療對腫瘤代謝微環境及表觀重編程的影響和具體機制。

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1. Xin Yin, Xu Teng, Tianyu Ma, Tianshu Yang, Jingyao Zhang, Miaomiao Huo, Wei Liu, Yunkai Yang, Baowen Yuan, Hefen Yu, Wei Huang*, Yan Wang*. RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis. Cell Death & Differentiation 2022, DOI: 10.1038/s41418-022-01010-2. (IF=12.067)

2. Wei Huang, Jingyao Zhang, Miaomiao Huo, Jie Gao, Tianshu Yang, Xin Yin, Pei Wang, Shuai Leng, Dandan Feng, Yang Chen, Yang Yang, Yan Wang*. CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway. Advanced Science 2021; 8(10): 2001515. (IF=17.521)

3. Shuai Leng, Wei Huang, Yang Chen, Yang Yang, Dandan Feng, Wei Liu, Tianyang Gao, Yanli Ren, Miaomiao Huo, Jingyao Zhang, Yunkai Yang, Yan Wang*. SIRT1 Coordinates with the CRL4B Complex to Regulate Pancreatic Cancer Stem Cells to Promote Tumorigenesis. Cell Death & Differentiation 2021; 28(12): 3329-3343. (IF=12.067)

4. Jie Gao^#, Ruiqiong Liu^#, Dandan Feng^#, Wei Huang, Miaomiao Huo, Jingyao Zhang, Shuai Leng, Yang Yang, Tianshu Yang, Xin Yin, Xu Teng, Hefen Yu, Baowen Yuan, Yan Wang*. Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition. Cell Death & Differentiation 2021; 28(9): 2818-2836. (IF=12.067)

5. Tianshu Yang, Pei Wang, Xin Yin, Jingyao Zhang, Miaomiao Huo, Jie Gao, Gen Li, Xu Teng, Hefen Yu, Wei Huang, Yan Wang*. The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer. Theranostics 2021; 11(5), 2058-76. (IF=11.6)

6. Yongqiang Hou, Wei Liu, Xianfu Yi, Yang Yang, Dongxue Su, Wei Huang, Hefen Yu, Xu Teng, Ying Yang, Wei Feng, Tao Zhang, Jie Gao, Kai Zhang, Rongfang Qiu, Yan Wang*. PHF20L1 as a Novel H3K27me2 Reader Coordinates with Transcriptional Repressors to Promote Breast Tumorigenesis. Science Advances 2020; 6(16), eaaz0356. (IF=14.136)

7. Yi Zeng^#, Rongfang Qiu^#, Yang Yang^#, Tianyang Gao, Yu Zheng, Wei Huang, Jie Gao, Kai Zhang, Ruiqiong Liu, Shuang Wang, Yongqiang Hou, Wenqian Yu, Shuai Leng, Dandan Feng, Wei Liu, Xi Zhang, Yan Wang*. Regulation of EZH2 by SMYD2-Mediated Lysine Methylation is Implicated in Tumorigenesis. Cell Reports 2019; 29: 1482-1498. (IF=8.109)

8. Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang*, Yongfeng Shang*. Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2- Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell 2015; 27(6): 822-36. (IF=23.214)

9. Huili Hu, Yang Yang, Qinghong Ji, Wei Zhao, Baichun Jiang, Ruiqiong Liu, Jupeng Yuan, Qiao Liu, Xi Li, Yongxin Zou, Changshun Shao, Yongfeng Shang, Yan Wang*, Yaoqin Gong*. CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell 2012; 22(6): 781-95. (IF=24.755)

10.Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Yanyan Li, Yu Zhang, Qian Li, Xia Yi, and Yongfeng Shang*. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 2009; 138(4): 660-72. (IF=31.152, C100)