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藥物研究所

個人簡介

張金蘭,1969年生,籍貫內蒙古呼和浩特,藥物分析學家,藥物研究所研究員,博士生導師。1987年考入北京醫(yī)科大學藥學專業(yè),1992年獲得學士學位。1992年在中國協(xié)和醫(yī)科大學藥物分析專業(yè)攻讀碩士學位,從事中藥成分分離和分析研究。1999年在中國協(xié)和醫(yī)科大學藥物分析專業(yè)攻讀博士學位,從事中草藥代謝產物分析研究。2002年進入北京大學醫(yī)學部進行博士后研究工作,主要研究中草藥成分分析和體內代謝研究。 1998年升為助理研究員。2000年破格升為副研究員,2007年聘任為研究員。


主要研究方向

聚焦藥物分析新技術及方法研究與應用。構建基于色譜質譜聯(lián)用和多維數據分析的藥物分析關鍵技術平臺,重點解決藥物關鍵質量屬性和體內分析技術瓶頸,支撐藥物質量分析、藥代動力學研究和藥效評價。


代表性成果

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1. Jin-Lan Zhang#, Yu-Huan Li#, Lu-Lu Wang#, Hong-Qi Liu#, Shuai-Yao Lu#, Yong Liu, Ke Li, Bin Liu, Su-Yun Li, Feng-Min Shao, Kun Wang, Ning Sheng, Rui Li, Jin-Jin Cui, Pei-Chun Sun, Chun-Xia Ma, Bo Zhu, Zhe Wang, Yuan-Hao Wan, Shi-Shan Yu, Yongsheng Che, Chao-Yang Wang, Chen Wang, Qiangqian Zhang, Li-Min Zhao, Xiao-Zhong Peng*, Zhenshun Cheng*, Jun-Biao Chang* , Jian-Dong Jiang*, Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients,  Signal Transduction & Targeted Therapy, 2021, 6(1), 414. (IF=38.104)

2. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide. Journal of Pharmaceutical Analysis,  2021, 11, 764-775. (IF=14.026)

3. Miao Lin#, Menglin Li#, Hao Zheng, Haidan Sun, Jinlan Zhang*. Lipoprotein proteome profile: novel insight into hyperlipidemia, Clinical and Translational Medicine.2021, doi=10.1002/ctm2.361.(IF=8.554)

4. Menglin Li#, Hao Zheng, Miao Lin, Wenwen Zhu, Jinlan Zhang*. Characterization of the protein and peptide of excipient zein by the multienzyme digestion coupled with nano-LC-MS/MS. Food Chemistry, 2020, 321: 126712. (IF=7.514)

5. Wenwen Zhu#, Menglin Li#, Jinlan Zhang*, Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity.  Journal of Proteome Research, 2020. doi=10.1021/acs.jproteome.0c00373. (IF=5.37)

6. Ning Sheng#, Hao Zheng#, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu*, Jinlan Zhang*. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacological Research, 2020, 152C, 104636. (IF=7.658)

7. Miao Lin# , Xiong Chen# , Zhe Wang , Dongmei Wang*, Jinlan Zhang*, Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acids. Analytica Chimica Acta, 10.1016/j.aca.2020.07.067. (IF=6.558)

8. Miao Lin #, Zhe Wang , Dongmei Wang, Xiong Chen, Jinlan Zhang*, A mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamster.Analytical chemistry, 2019, 91, 4504–4512.(IF=6.785)

9. Hu T#, Jia ZX, Zhang JL.*, Strategy for Comprehensive Pro?ling and Identication of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. Analytical chemistry, 2017, 89, 7808?7816.(IF=6.042)

10. Tie C#, Hu T#, Jia ZX, Zhang JL.*, Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring.  Analytical chemistry, 2016, 88,7762-7768.(IF=6.320)