黃粵，1973年生，分子遺傳學(xué)與干細(xì)胞生物學(xué)家，基礎(chǔ)醫(yī)學(xué)研究所研究員，博士生導(dǎo)師。1994年在吉林大學(xué)獲分子生物學(xué)學(xué)士學(xué)位；1997年在中山大學(xué)獲分子遺傳學(xué)碩士學(xué)位； 2000年在中國協(xié)和醫(yī)科大學(xué)獲生化與分子生物學(xué)博士學(xué)位。留校在生化系工作，任助理研究員，主要從事成簇基因表達(dá)調(diào)控機(jī)制研究。2004年赴英國劍橋Sanger研究所進(jìn)行博士后研究，主要從事基因純合突變體文庫構(gòu)建和功能遺傳篩選。2009年回國在醫(yī)學(xué)遺傳學(xué)系工作至今，2010年升為研究員。

利用多能干細(xì)胞和動物模型研究干細(xì)胞分化、個體發(fā)育和腫瘤形成過程中的內(nèi)在分子機(jī)制,同時開展遺傳病基因治療的研究。近期在基于單倍體干細(xì)胞的功能遺傳篩選、異倍體促進(jìn)腫瘤發(fā)生發(fā)展及轉(zhuǎn)移，等方面取得重要進(jìn)展。

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1. Zuo ZY#, Yang GH#, Wang HY#, Liu SY, Zhang YJ, CaiY, Chen F, Dai H, Xiao Y, Cheng MB*, Huang Y*, Zhang Y*. Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm. Nucleic Acids Research, 50(4): 2005-2018, 2022. (IF=19.16)

2. Wang X#, Ping C#, Tan P#, Sun C, Liu G, Liu T, Yang S, Si Y, Zhao L, Hu Y, Jia Y, Wang X, Zhang M, Wang F, Wang D*, Yu J*, Ma Y*, Huang Y*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. the EMBO Journal, 40 (4): e104729, 2021. (IF=11.598)

3. Zhang GZ#, Li XW#, Sun Y, Wang X, Liu G*, Huang Y*. A genetic screen identifiesEtl4-deficiency capable of stabilizing the haploidy in embryonic stem cells. Stem Cell Reports, 16 (1): 29-38, 2021. (IF=7.765)

4. Rui Yang#, Huanmin Wang#, Boxi Kang, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Ping Xu, Yongsheng Chang, Yuyan Jia*, Yue Huang*, CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development.146(2): dev.169235, 2019. (IF=5.763)

5. Guang Liu#, Xue Wang#, Yufang Liu#, Meili Zhang, Tao Cai, Zhirong Shen, Yuyan Jia，Yue Huang*. Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens. Nucleic Acids Research, 45(22): e180, 2017. (IF=11.147)

6. Meili Zhang#, Li Cheng, Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley, Yue Huang*. Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential. the EMBO Journal. 35(21): 2285-2300, 2016. (被選為封面論文，并配以 “News & Views” 專題評論) (IF=9.643)

7. Yanni Ma#, Nan Yao#, Guang Liu#, Dong L, Liu Y, Zhang M, Wang F, Wang B, Wei X, Dong H, Wang L, Ji S, Zhang J, Wang Y, Yue Huang*， Jia Yu*.  Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. the EMBO Journal. 34(3): 361–378, 2015. (IF=10.434)

8. Meili Zhang#, Yufang Liu#, Guang Liu#, Xin Li#, Yuyan Jia, Lihong Sun, Liu Wang, Qi Zhou，Yue Huang*. Rapidly Generating Knockout Mice from H19-Igf2 Engineered Androgenetic Haploid Embryonic Stem Cells. Cell Discovery. 1: e15031, 2015. (IF=4.462)

9. Yue Huang# *, Stephen J. Pettitt#, Ge Guo, Guang Liu, Meng Amy Li, Fengtang Yang，Allan Bradley*, Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system. Nucleic Acids Research, 40(3): e21, 2012. (IF=8.808)

10. Wei Wang, Allan Bradley*, Yue Huang*. A PiggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. Genome Research. 19(4):667-73, 2009. (IF=10.176)