范武發(fā)，1989年生，籍貫福建龍巖，從事藥劑學(xué)研究，中國(guó)醫(yī)學(xué)科學(xué)院藥物研究所研究員，博士生導(dǎo)師。2008年考入福建中醫(yī)藥大學(xué)藥物制劑專業(yè)，2012年獲得學(xué)士學(xué)位。2012年在鄭州大學(xué)藥劑學(xué)專業(yè)攻讀碩士學(xué)位，2015年獲得碩士學(xué)位，從事納米藥物遞送研究。2015年在復(fù)旦大學(xué)藥劑學(xué)專業(yè)攻讀博士學(xué)位，2019年獲得博士學(xué)位，從事納米藥物遞送研究。2019-2022年進(jìn)入北京大學(xué)化學(xué)與分子工程學(xué)院進(jìn)行博士后研究工作，從事納米藥物遞送研究。

生物醫(yī)用高分子材料的合成與應(yīng)用；納米藥物跨生物屏障遞送及機(jī)制；納米藥物腫瘤免疫治療；多肽、蛋白、核酸等大分子藥物遞送；納米藥物生物學(xué)效應(yīng)

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1. Wufa Fan#, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao*, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li*, Youqing Shen*. Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery. Adv Mater 34(16):e2109189. (IF=32.086)

2. Wufa Fan#, Haixia Peng, Zhou Yu, Luting Wang, Haisheng He, Yuhua Ma, Jianping Qi, Yi Lu, Wei Wu*. The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers. Acta Pharm Sin B 12(5):2479-2493. (IF=14.903)

3. Siqin Chen#, Yin Zhong#, Wufa Fan#, Jiajia Xiang#, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, Youqing Shen*. Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity. Nat Biomed Eng 5(9):1019-1037. (IF=29.234, ESI)

4. Yisi Tang#, Wufa Fan#, Guihua Chen, Meng Zhang, Xueping Tang, Hairui Wang, Pengfei Zhao, Qin Xu, Zhibing Wu*, Xiaoxi Lin, Yongzhuo Huang*. Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment. Nano Today 40:101244. (IF=18.962)

5. Wufa Fan#, Zhou Yu#, Haixia Peng, Haisheng He, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu*. Effect of particle size on the pharmacokinetics and biodistribution of parenteral nanoemulsions. Int J Pharm 586:119551. (IF=5.875)

6. Zhou Yu#, Wufa Fan#, Luting Wang, Haisheng He, Yongjiu Lv, Jianping Qi, Yi Lu, Wei Wu*. Slowing down lipolysis significantly enhances the oral absorption of intact solid lipid nanoparticles. Biomater Sci 7(10):4273-4282. (IF=6.183)