賈美榮，1987年生，籍貫山東，中國醫(yī)學(xué)科學(xué)院藥物研究所研究員，博士生導(dǎo)師。2009年獲得山東大學(xué)制藥工程專業(yè)學(xué)士學(xué)位。2012年取得山東大學(xué)藥物化學(xué)專業(yè)碩士學(xué)位，從事抗腫瘤藥物研究。2016年取得美國Iowa State University生物化學(xué)專業(yè)博士學(xué)位，從事萜類生物合成研究。2016-2019年分別在美國Iowa State University和美國University of California, Davis進(jìn)行博士后研究工作，主要進(jìn)行萜類合成生物學(xué)研究。2021年作為助理教授到北京協(xié)和醫(yī)學(xué)院藥物研究所工作。

本人致力于萜類等藥用植物來源的活性天然物質(zhì)的挖掘、生物合成、結(jié)構(gòu)優(yōu)化和異源生產(chǎn)，主要包括:基于整合組學(xué)的活性天然產(chǎn)物的功能基因元件挖掘和鑒定；結(jié)合計算模擬的生物酶催化機(jī)制闡明和功能設(shè)計改造；基于多元底盤的天然產(chǎn)物及中間體的高效異源生產(chǎn)和結(jié)構(gòu)優(yōu)化。

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1. Muchlinski A#, Jia M#, Tiedge K#, Fell J, Pelot K, Chew L, Davisson D, Chen Y, Siegel J, Lovell J, and Zerbe P*. Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.). Plant J, 2021, 108: 1053–68 (IF = 6.417).

2. Jia M#, Zhang Y#, Siegel JB*, Tantillo DJ*, and Peters RJ*. Switching on a nontraditional enzymatic base–deprotonation by serine in the ent-kaurene synthase from Bradyrhizobium japonicum. ACS Catal. 2019, 9:8867-71 (IF = 11.406).

3. Jia M#, Mishra S, Tufts S, Jernigan R, and Peters RJ*. Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases. Metab Eng. 2019, 55:44-58 (IF = 7.875).

4. Jia M#, O’Brien TE, Zhang Y, Siegel JB, Tantillo DJ, and Peters RJ*. Changing face: A key residue for the addition of water by sclareol synthase. ACS Catal. 2018, 8:3133-7 (IF = 10.435).

5. Jia M#, Zhou K, Tufts S, Schulte S, and Peters RJ*. A pair of residues that interactively affect diterpene synthase product outcome. ACS Chem. Biol. 2017, 12(3):862-7 (IF = 5.139).

6. Jia M#, and Peters RJ*. Cis or Trans with class II diterpene cyclases. Org Biomol, 2017, 15:3158-60 (IF = 3.562).

7. Jia M#, Potter KC, and Peters RJ*. Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis. Metab Eng. 2016, 37:24-34 (IF = 7.742).

8. Jia M#, and Peters RJ*. Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases. Front Plant Sci. 2016, 7:1765 (IF = 4.027).

9. Jia M#, Yang K, Fang H, Xu Y, Sun S, Su L, and Xu W*. Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine. Bioorg Med Chem. 2011, 19:5190-8 (IF = 2.958).