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藥物研究所

個人簡介

耿軼群,1983年生,籍貫河南,化學生物學家,藥物所研究員,博士生導師。2001年考入北京大學藥學專業,2005年獲得學士學位。2005-2007年在北京大學藥學院化學生物學專業攻讀碩士學位,從事糖化學研究。2007-2011年在北京大學藥學院化學生物學專業攻讀博士學位,從事糖化學生物學研究。2011-2019年在德國康斯坦茨大學化學系和英國牛津大學化學系進行博士后研究工作,主要研究糖化學生物學和糖類藥物。2010年聘為研究員/助理教授。


主要研究方向

以攻克威脅人類健康的重大疾病為導向,以探索和調控內源性糖類活性物質在生理、病理過程中的關鍵作用為核心科學問題,利用化學生物學手段,為相關疾病提供新的診治靶標和先導化合物類型,驅動糖類創新藥物研究。


代表性成果

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1. Yingxin Shi#, Sheng Yan, Guang-Can Shao, Jinglong Wang, Yong-Ping Jian, Bo Liu, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng-Qiu Dong, Yiqun Geng*, Zhi-Xiang Xu*, Jing Li*. O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection. J. Biol. Chem. 2022, doi: 10.1016/j.jbc.2022.102341. (IF=5.486)

2. Cara A. Griffiths#, Ram Sagar#, Yiqun Geng#, Lucia F. Primavesi, Mitul K. Patel, Melissa K. Passarelli, Ian S. Gilmore, Rory T. Steven, Josephine Bunch, Matthew J. Paul*, Benjamin G. Davis*. Chemical intervention in plant sugar-signalling increases yield and resilience. Nature 2016, 540 (7634), 574-578. (IF=40.137, C100, ESI)

3. Yiqun Geng#, Amit Kumar, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. Cooperative Catalysis in Glycosidation Reactions with O-Glycosyl Trichloroacetimidates as Glycsoyl Donors. Angew. Chem. Int. Ed. 2013, 52 (38), 10089-10092. (IF=11.336)

4. Yiqun Geng#, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. C-(α-d-Glucopyranosyl)-phenyldiazomethanes-irreversible inhibitors of α-glucosidase. Bioorg. Med. Chem. 2013, 21 (16), 4793-4802. (IF=2.951)

5. Yiqun Geng#, Hassan M. Faidallah, Hassan A. Albar, Ibrahim, A. Mhkalid, Richard R. Schmidt*. Organocatalysis for the Acid-Free O-Arylidenation of Carbohydrates. Eur. J. Org. Chem. 2013 (31), 7035-7040. (IF=3.154)

6. Yiqun Geng#, Qi Qin, Xin-Shan Ye*. Lewis Acids as α-Directing Additives in Glycosylations by Using 2,3-O-Carbonate-Protected Glucose and Galactose Thioglycoside Donors Based on Preactivation Protocol. J. Org. Chem. 2012, 77 (12), 5255-5270. (IF=4.564)

7. Yiqun Geng#, Xin-Shan Ye*. Additive-Controlled Stereoselective Glycosylations of Oxazolidinone-Protected Glucosamine and Galactosamine Thioglycoside Donors Based on Preactivation Protocol. Synlett 2010 (16), 2506-2512. (IF=2.447)

8. Yiqun Geng#, Li-He Zhang, Xin-Shan Ye*. Stereoselectivity investigation on glycosylation of oxazolidinone protected 2-amino-2- deoxy-D-glucose donors based on pre-activation protocol. Tetrahedron 2008, 64 (22), 4949-4958. (IF=2.897)

9. Yiqun Geng#, Li-He Zhang, Xin-Shan Ye*. Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamine. Chem. Commun. 2008(5), 597-599.(IF=5.340)