姜明紅，1976年生，籍貫遼寧金縣，免疫學(xué)專業(yè)，中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所研究員，博士生導(dǎo)師。1995年考入哈爾濱醫(yī)科大學(xué)臨床學(xué)專業(yè)，2000年獲得學(xué)士學(xué)位。2002年在第二軍醫(yī)大學(xué)腫瘤學(xué)專業(yè)攻讀碩士學(xué)位，從事腫瘤基因治療研究。2005年在上海復(fù)旦大學(xué)遺傳學(xué)專業(yè)攻讀博士學(xué)位，從事表觀遺傳學(xué)研究。2008年進(jìn)入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所工作，主要研究感染與炎癥的分子機(jī)制。 2012年為副研究員。2018年為研究員。

聚焦感染、自身免疫性疾病以及腫瘤的重要調(diào)控新分子，揭示免疫與炎癥調(diào)控新機(jī)制。通過鑒定免疫相關(guān)疾病的新型藥物靶點(diǎn)，研制具有自主知識(shí)產(chǎn)權(quán)的新型免疫治療技術(shù)及產(chǎn)品，形成原創(chuàng)性的科研成果與轉(zhuǎn)化醫(yī)學(xué)體系。

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1. Cheng Wang#, Wenkai Zhou, Yin Liu, Yue Xu, Xuan Zhang, Chengyu Jiang, Minghong Jiang*, Xuetao Cao*. Nuclear translocation of RIG-I promotes cellular apoptosis. J Autoimmun. 2022 Jun;130:102840. (IF=14.511)

2. Wei Liu#, Ziqiao Wang, Lun Liu, Zongheng Yang, Shuo Liu, Zhongfei Ma, Yin Liu, Yuanwu Ma, Lianfeng Zhang, Xuan Zhang, Minghong Jiang*, Xuetao Cao*. LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity. Proc Natl Acad Sci USA. 2020 Sep 22;117(38):23695-23706. (IF=10.414)

3. Xiaoqi Song#, Shuo Liu, Wendie Wang, Zhongfei Ma, Xuetao Cao, Minghong Jiang*. E3 ubiqitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. Cell Mol Immunol. 2020 Aug;17(8):865-874. (IF=8.213)

4. Hongyu Lin#, Minghong Jiang#, Lun Liu, Zhongfei Ma, Shuo Liu, Zongheng Yang, Yuanwu Ma, Lianfeng Zhang, Xuetao Cao*.    The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response. Nat Immunol. 2019 Jul;20(7):812-823.(IF=23.906)

5. Minghong Jiang#, Shikun Zhang#, Zongheng Yang, Hongyu Lin, Jun Zhu, Lun Liu, Wendie Wang, Shuo Liu, Wei Liu, Yuanwu Ma, Lianfeng Zhang, Xuetao Cao*. Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response. Cell. 2018 May 3;173(4):906-919.e13. (IF=36.43, F1000)

6. Shuo Liu#, Minghong Jiang#, Wendie Wang, Wei Liu, Xiaoqi Song, Zhongfei Ma, Shikun Zhang, Lun Liu, Yin Liu, Xuetao Cao*.Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA.     Nat Immunol. Nat Immunol. 2018 Jan;19(1):41-52. (IF=23.906)    

7. Wendie Wang#, Minghong Jiang#, Shuo Liu, Shikun Zhang, Wei Liu, Yuanwu Ma, Lianfeng Zhang, Jiyan Zhang, Xuetao Cao*.RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci USA. 2016 Aug 23;113(34):9581-6. (IF=10.414)

8. Minghong Jiang#, Yang Xiang#, Dongsheng Wang, Jing Gao, Dan Liu, Yanxin Liu, Shilian Liu, Dexian Zheng*. Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell. 2012 Feb;11(1):29-40. (IF=9.304)

9. MH Jiang#, J Fei, MS Lan, ZP Lu, M Liu, WW Fan, X Gao, DR Lu*. Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia. 2008 Aug;51(8):1525-33. (IF=10.122)

10. Minghong Jiang#, Wenfang Shi#, Qi Zhang#, Xinhua Wang, Minggao Guo, Zhenfu Cui, Changqin Su, Qing Yang, Yuemin Li, Jonathan Sham, Xinyuan Liu, Mengchao Wu, Qijun Qian*. Gene therapy using adenovirus-mediated full-length anti-HER-2 antibody for HER-2 overexpression cancers. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6179-85. (IF=12.531)