楊沛然，1990年生，籍貫北京，從事呼吸系統疾病及肺血管病研究，基礎醫學研究所副研究員，博士生導師。2008年考入英國劍橋大學自然科學專業，2011年獲得學士學位。2011年在劍橋大學生物醫學專業攻讀碩士學位，從事心血管及代謝疾病研究。2013年在劍橋大學生物醫學專業攻讀博士學位，從事肺血管病研究。2017年進入哈佛大學醫學院進行博士后研究工作，主要研究肺動脈高壓的發病機制研究及新藥研發。2021年以“引進人才”加入基礎醫學研究所。

肺血管病變的發生機制與干預：探究不同類型肺動脈高壓中血管病變的共有分子改變；構建肺血管病變的類器官及跨物種動物模型，開展靶向挖掘及藥物篩選；利用干細胞及衍生物改善肺血管微環境，開展干預手段研究。

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1. Yang P#, Bocobo GA, Yu PB*. Sotatercept for Pulmonary Arterial Hypertension. N Engl J Med 2021 385(1):92-93. (IF=91.3)

2. Yang P#, Yu PB*. Periostin: A Novel Integrator of Hypoxic Signaling in Pulmonary Hypertension. Circ Res. 2020 127(9):1153-1155. (IF=14.5)

3. Yang P#, Troncone L, Augur ZM, Kim SSJ, McNeil ME, Yu PB*. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 141:115542. (IF=4.1)

4. Yung LM#, Yang P#, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB*. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 12(543):eaaz5660. (IF=16.3)

5. Yang P#, Read C#, Kuc RE, Nyimanu D, Williams TL, Crosby A, Buonincontri G, Southwood M, Sawiak SJ, Morrell NW, Davenport AP, Maguire JJ*. A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br J Pharmacol. 2019 176(9):1206-1221. (IF=6.6)

6. Yang P#, Yu PB*. In Search of the Second Hit in Pulmonary Arterial Hypertension. Circ Res. 2019 124(1):6-8. (IF=15.9)

7. Yang P#, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ*, Davenport AP*. Elabela/Toddler Is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation. 2017 135(12):1160-1173. (IF=19.3, ESI)

8. Yang P#, Kuc RE, Brame AL, Dyson A, Singer M, Glen RC, Cheriyan J, Wilkinson IB, Davenport AP, Maguire JJ*. [Pyr1]Apelin(1-12) is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr1]Apelin-13. Front Neurosci. 2017 11:92. (IF=3.6)

9. Read C#, Fitzpatrick CM#, Yang P#, Kuc RE, Maguire JJ*, Glen RC*, Foster RE*, Davenport AP*. Cardiac action of the first G protein biased small molecule apelin agonist. Biochem Pharmacol. 2016 116:63-72. (IF=5.1)

10. Yang P#, Maguire JJ, Davenport AP*. Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 2015 36(9):560-567. (IF=11.5)