蘭峰，1982年生，籍貫福建，從事心血管病學基礎和轉化研究，研究員，博士生導師。2000年考入中央民族大學生物科學專業，2004年獲得學士學位。2004-2009年在北京大學細胞生物學專業攻讀博士學位，從事多能干細胞生物學研究。2009-2014于斯坦福大學心血管研究所進行博士后研究工作。2014-2019進入首都醫科大學附屬北京安貞醫院，任教授，博導，并獨立帶領課題組開展遺傳性心臟病研究。2020年進入阜外醫院，2021年升為助理研究員。

采用最前沿的多能干細胞模型（hPSC）和堿基編輯技術，研究遺傳性心臟?。ㄐ募〔?、心律失常）的發病機制，建立一系列精準診斷和治療的新方法，并進行臨床應用轉化。建立了首個肥厚型心肌病iPS模型。帶領團隊首次采用堿基編輯器對肥厚型心肌病模型進行在體基因編輯治療。

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1. Jiang Y#, Li X#, Guo T#, Lu WJ, Ma S, Chang Y, Song Y, Zhang S, Bai R, Wang H, Qi M, Jiang H*, Zhang H*, Lan F*. Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes. Stem Cell Reports. 2022 Apr 12;17(4):804-819. (IF= 7.2935)

2. Ma S#, Jiang W#, Liu X#, Lu W, Qi t, Wei J, Wu F, Chang Y, Zhang S, Song Y, Rui Bai R, Wang J, Lee A, Zhang H*, Wang Y*, Lan F*. Efficient correction of a hypertrophic cardiomyopathy mutation by ABEmax-NG. Circulation Research, 2021, Oct 29;129(10):895-908. (IF= 23.2125)

3. Guo R, Wan F, Xu Q, Feng T, Yang H, Gong Y, Ma S, Chang Y, Zhang S, Jiang Y, Wang H, Chang D, Zhang H, Ling Y*, Lan F*. Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material. Bioactive Material, 2021, Mar 5;6(9):2999-3012. (IF= 16.8737)

4. Gao Y, Wu S, Pan J, Zhang K, Li X, Xu Y, Jin C, He X, Shi J, Ma L, Wu F, Yao Y, Wang P, He Q, Lan F*, Zhang H*, Tian M*. CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):708-720. (IF= 10.0567)

5. Wang D, Zhang C, Wang B, Li B, Wang Q, Liu D, Wang H, Zhou Y, Shi L, Lan F*, Wang Y*. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nature Communication. 2019 Sep 19;10(1):4284. (IF= 17.6939)

6. Li X, Lu W, Li Y, Wu F, Bai R, Ma S, Dong T, Zhong H, Lee A, Wang Y*, Lan F*. MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling. Cell Death Disease. 2019 Aug 13;10(8):610. (IF= 9.6854)

7. Ke B, Zeng Y, Zhao Z, Han F, Liu T, Wang J, Khalique A, Lu WJ, Chong J, Lan F*, He H*. Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification. Cell Death and Differentiation. 2019 May;26(5):826-842. (IF= 12.0673)

8. Jiang Q, Li K, Lu WJ, Li S, Chen X, Liu XJ, Yuan J, Ding Q, Lan F*, Cai SQ*. Identification of small-molecule ion channel modulators in C. elegans channelopathy models. Nature Communication. 2018 Sep 26;9(1):3941 (IF= 17.6939)

9. Lan F#,Lee AS#, Liang P#, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Navarrete EG, Wheeler M, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. Cell Stem Cell. 2013;12:101-113. (IF= 25.2698，F1000)

10. Lan F#, Liu J#, Narsinh KH, Hu S, Han L, Lee AS, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC*. Safe genetic modification of cardiac stem cells using a site-specific integration technique. Circulation. 2012;126:S20-28 (IF= 39.9175)