趙瑜，1984年出生，籍貫山東，中國醫學科學院放射醫學研究所研究員，博士生導師。2002年考入青島大學生物化學專業，獲得學士學位。2007年在南開大學攻讀博士學位，從事生物化學與分子生物學研究。2012年進入梅奧醫院攻讀博士后，并于2018年任梅奧醫院研究助理。2020年進入中國醫學科學院放射醫學研究所工作，2021年升為研究員。

基于抗腫瘤藥物機制的研究和基于反義寡核苷酸(ASO)合成技術開發腫瘤核素靶向藥物兩方面的突破性進展，主要從事腫瘤表觀遺傳學、放射表觀遺傳與轉錄調控、RNA藥物研發等領域的基礎研究和產品技術研發工作。

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1. Li Y#, Wang C#, Gao H#, Gu J, Zhang Y, Zhang Y, Xie M, Cheng X, Yang M, Zhang W, Li Y, He M, Xu H, Zhang H, Ji Q, Ma T, Ding S, Zhao Y*, Gao Y*. KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21CIP1 axis. Theranostics. 2022 Jun 21;12(11):4922-4934. (IF=11.600)

2. Chen L#, Liu H, Ji Y, Ma Z, Shen K, Shangguan X, Qian H, Zhao Y*, Pan CW*, Xue W*. Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition. Exp Cell Res. 2022 Jun 15;415(2):113138.  (IF=4.145)

3. Pan CW#, Wen S, Chen L, Wei Y, Niu Y, Zhao Y. Functional roles of antisense enhancer RNA for promoting prostate cancer progression. Theranostics. 2021 Jan 1;11(4):1780-1794.  (IF=11.600)

4. Wen S#, Wei Y#, Zen C, Xiong W, Niu Y*, Zhao Y*. Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine. Mol Cancer. 2020 Dec 12;19(1):171.  (IF=41.444)

5. Zhao Y#, Ding L, Wang D, Ye Z, He Y, Ma L, Zhu R, Pan Y, Wu Q, Pang K, Hou X, Weroha SJ, Han C, Coleman R, Coleman I, Karnes RJ, Zhang J, Nelson PS, Wang L, Huang H. EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. EMBO J. 2019 Mar 1;38(5):e99599.  (IF=14.012)

6. He Y#, Zhao Y#, Wang L#, Bohrer LR, Pan Y, Wang L, Huang H. LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation. Oncogene. 2018 Jan 25;37(4):534-543.  (IF=8.756)

7. Zhang P#, Wang D#, Zhao Y#, Ren S#, Gao K#, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y*, Wang C*, Huang H*. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017 Sep;23(9):1055-1062.  (IF=87.241)

8. Zhao Y#, Wang L, Ren S, Wang L, Blackburn PR, McNulty MS, Gao X, Qiao M, Vessella RL, Kohli M, Zhang J, Karnes RJ, Tindall DJ, Kim Y, MacLeod R, Ekker SC, Kang T, Sun Y*, Huang H*. Activation of P-TEFb by androgen receptor-Regulated enhancer RNAs in castration-Resistant prostate cancer. Cell Rep. 2016 Apr 19;15(3):599-610.  (IF=9.995)

9. Zhao Y#, Li H#, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang X*, Ye L*. Oncoprotein HBXIP modulates abnormal lipid metabolism and growth of breast cancer cells by activating the LXRs/SREBP-1c/FAS signaling cascade. Cancer Res. 2016 Aug 15;76(16):4696-707.  (IF=13.312)

10. Zhao Y#, Tindall DJ, Huang H. Modulation of androgen receptor by FOXA1 and FOXO1 factors in prostate cancer. Int J Biol Sci. 2014 Jun 5;10(6):614-9.  (IF=10.750)