王明榮，1956年生，籍貫安徽，腫瘤分子細(xì)胞生物學(xué)家，中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院研究員，博士生導(dǎo)師。1977年考入安徽師范大學(xué)大學(xué)生物系，1982年獲得學(xué)士學(xué)位。2005-2008年在皖南醫(yī)學(xué)院組織胚胎學(xué)專業(yè)攻讀碩士學(xué)位，從事細(xì)胞衰老研究。1991-1993年在法國克萊蒙大學(xué)攻讀博士學(xué)位，從事膀胱癌遺傳學(xué)研究。1993-1994年在克萊蒙大學(xué)進(jìn)行博士后工作，進(jìn)行腫瘤遺傳學(xué)研究。1990年升為講師，1995年獲法國生物科學(xué)講師資格，1996年升為副研究員，1997年破格升為研究員。

癌變分子機(jī)理及腫瘤分子標(biāo)志：著重闡釋腫瘤發(fā)生發(fā)展過程中細(xì)胞增殖、侵襲、凋亡的分子機(jī)制，發(fā)現(xiàn)癌前預(yù)警、腫瘤診斷及預(yù)后的分子標(biāo)志，鑒定腫瘤預(yù)防、治療的分子靶點(diǎn)。

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1. Lin DC*, Wang MR*, Koeffler HP. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 2018; 154(2):374-389. (IF= 20.773, C100)

2. Jiang YY#*, Lin DC#*, Mayakonda A#, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR*, Koeffler HP. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. 2017; 66(8):1358-1368. (IF= 16.658, C100)

3. Hao JJ#, Lin DC#*, Dinh HQ#, Mayakonda A#, Jiang YY#, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ*, Berman BP*, Wang MR*, Koeffler HP. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016; 48(12):1500-1507. (IF= 31.616, C100)

4. Liu YZ, Yang H, Cao J, Jiang YY, Hao JJ, Xu X, Cai Y, Wang MR*. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer. Sci Rep. 2016; 6:24786. (IF= 5.228, F1000)

5. Lin DC#*, Hao JJ#, Nagata Y#, Xu L#, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ , Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR*, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nature Genetics 2014; 46(5):467-73. (IF= 29.648, C100)

6. Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR*. Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res. 2013; 19(21):5867-78. (IF=7.827)

7. Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng HY, Cui JL, Zhang TT, Wang YQ, Zhang HB, Zhan QM, Wang MR*. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012; 142(3):521-530.e3. (IF=11.675, F1000)

8. Du XL, Hu H, Lin DC, Xia SH, Shen XM, Zhang Y, Luo ML, Feng YB, Cai Y, Xu X, Han YL, Zhan QM, Wang MR*. Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma. J Mol Med. 2007; 85(8):863-75. (IF=5.157, F1000/C100)

9. Luo ML, Shen XM, Zhang Y, Wei F, Xu X, Cai Y, Zhang X, Sun YT, Zhan QM, Wu M, Wang MR*. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 2006; 66(24):11690-9. (IF=7.656, C100)

10. Hu H, Xia SH, Li AD, Xu X, Cai Y, Han YL, Wei F, Chen BS, Huang XP, Han YS, Zhang JW, Zhang X, Wu M, Wang MR*. Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int J Cancer. 2002; 102(6):580-3. (IF=4.233, C100)