庾石山，博士，研究員，博士生導師。1993年畢業于中國協和醫科大學藥物化學專業獲理學博士學位，1995-1996年在奧地利維也納大學作博士后研究。現任藥物研究所副所長、“天然藥物活性物質與功能”國家重點實驗室主任。杰青、國家級重大人才項目入選者（教育部）、國家衛生計生委“有突出貢獻的中青年專家”。主要從事天然藥物化學和創新藥物研究，在中草藥（包括瀕危動物藥材）活性物質的化學研究、新藥創制及重大原創藥物的成果轉化等方面取得系統性和原創性成果。

主要從事瀕危動物藥材和有毒藥用植物中新穎結構藥效分子的發現、結構與功能及創新藥物研究，具體包括：瀕危動物藥材藥效物質及原創替代品研究；顯著活性小分子天然產物的化學生物學研究；基于天然產物的原創藥物研究。

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1. Sheng Liu, Chunyan Wei, Tian Liu, Shuang-Gang Ma, Chen Chen, Hao Lin, Lianhui Zhang, Heng Wang*, Chong-Jing Zhang* & Shi-Shan Yu*. A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors. Signal Transd. Target. Ther. 2022,7,160. (IF=38.126)

2. Ru-Bing Wang#, Shuang-Gang Ma#*, Cooper S. Jamieson#, Rong-Mei Gao, Yun-Bao Liu, Yong Li, Xiao-Jing Wang, Yu-Huan Li, Kendall N. Houk*, Jing Qu* and Shi-Shan Yu*. Library construction of stereochemically diverse isomers of spirooliganin: their total synthesis and antiviral activity. Chem. Sci. 2021,12,7003-7011. (IF=9.969)

3. Yong Li, Yu-Xun Zhu, Zhao-Xin Zhang, Li Li, Yun-Bao Liu, Jing Qu, Shuang-Gang Ma, Shi-Shan Yu*. Antinociceptive grayanane-derived diterpenoidsfrom flowers of Rhododendron mole. Acta Pharm. Sin. B. 2020,10(6),1073-1082. (IF=11.614)

4. Chunyan Wei#, Cheng-Xiao Zhao#, Sheng Liu#, Jin-Hui Zhao#, Zi Ye, Heng Wang*, Shi-Shan Yu* and Chong-Jing Zhang*. Activity-based protein profiling reveals that secondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites. Chem. Commun. 2019,55(64),9535-9538. (IF=5.996)

5. Jian Bai#, Dao-Jiang Yan#, Tao Zhang, Yong-Zhi Guo, Yun-Bao Liu, Yi Zou, Man-Cheng Tang, Bing-Yu Liu, Qiong Wu, Shi-Shan Yu*, Yi Tang*, You-Cai Hu*. A Cascade of Redox Reactions Generates Complexityin the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Edit. 2017,56(17),4782-4786. (IF=12.102, F1000)

6. Chang-Shan Niu, Yong Li, Yun-Bao Liu, Shuang-Gang Ma, Fei Liu, Li Li, Song Xu, Xiao-Jing Wang, Ru-Bing Wang, Jing Qu*, Shi-Shan Yu*. Pierisketolide A and Pierisketones B and C, Three Diterpenes with an Unusual Carbon Skeleton from the Roots of Pieris formosa. Org. Lett. 2017,19(4),906-909. (IF=6.492)

7. Fang-Yi Su, Zheng Zhao, Shuang-Gang Ma, Ru-Bing Wang, Yong Li, Yun-Bao Liu, Yu-Huan Li, Li Li, Jing Qu*, Shi-Shan Yu*. Cnidimonins A-C, Three Types of Hybrid Dimer from Cnidium monnieri: Structural Elucidation and Semisynthesis. Org. Lett. 2017,19,4920-4923. (IF=6.492)

8. Shuang-Gang Ma, Mi Li, Ming-Bao Lin, Li Li, Yun-Bao Liu, Jing Qu*, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, Shi-Shan Yu*. Illisimonin A, a Caged Sesquiterpenoid with a Tricyclo[5.2.1.01,6]decane Skeleton from the Fruits of Illicium simonsii. Org. Lett. 2017,19,6160-6163. (IF=6.492)

9. Zhong-Hai Tang#, Yun-Bao Liu#, Shuang-Gang Ma#, Li Li, Yong Li, Jian-Dong Jiang, Jing Qu*, Shi-Shan Yu*. Antiviral Spirotriscoumarins A and B: Two Pairs of Oligomeric Coumarin Enantiomers with a Spirodienone-Sesquiterpene Skeleton from Toddalia asiatica. Org. Lett. 2016, 18(19), 5146-5149. (IF=6.579)

10.Ya-Dan Wang#, Xiu-Qi Bao#, Song Xu, Wen-Wen Yu, Sheng-Nan Cao, Jin-Ping Hu, Yong Li, Xiao-Liang Wang, Dan Zhang*, Shi-Shan Yu*. A Novel Parkinson’s Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. J. Med. Chem. 2016,59(19),9062-9079. (IF=6.259)