黃波，2002年在華中科技大學(xué)同濟(jì)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)系，獲得博士學(xué)位。于2002年-2006年，先后在瑞典Karolinska Institute（乳腺癌的遺傳學(xué)）、加拿大University of Calgary（腦膠質(zhì)瘤的生物學(xué)）、美國Mount Sinai School of Medicine（腫瘤免疫學(xué)和免疫治療）從事博士后研究。2006年初回國，任華中科技大學(xué)同濟(jì)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)系副教授，2008年破格晉升為教授、博士生導(dǎo)師，2012年調(diào)入醫(yī)科院基礎(chǔ)所免疫系從事腫瘤免疫方向的研究，現(xiàn)任中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所副所長(zhǎng)。

圍繞腫瘤免疫治療，T細(xì)胞和腫瘤代謝，腫瘤生物治療，腫瘤生物機(jī)械力，干細(xì)胞體外培養(yǎng)及擴(kuò)增，腫瘤休眠，CAR-T細(xì)胞治療以及臨床免疫治療等方面開展了深入研究。

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1. Zhang H#, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B*. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Molecular Cell. 2022;17:S1097-2765(22)00538-X. (IF=17.970)

2. Lv J#, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B*. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nature Cell Biology. 2022;24:364-72. (IF=28.123)

3. Liu Y#, Zhou N#, Zhou L#, Wang J, Zhou Y, Zhang T, Fang Y, Deng J, Gao Y, Liang X, Lv J, Wang Z, Xie J, Xue Y, Zhang H, Ma J, Tang K, Fang Y, Cheng F, Zhang C, Dong B, Zhao Y, Yuan P, Gao Q, Zhang H, Xiao-Feng Qin F, Huang B*. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Nature Immunology. 2021;22(3):358-369. (IF=31.25)

4. Lv J#, Liu Y, Cheng F, Li J, Zhou Y, Zhang T, Zhou N,Wang N, Liu Y, Huang B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J.2021;40(2):e106123. (IF=14.012)

5. Gao Y#, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y, Wang X, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nature Biomedical Engineering.2020;4(7):743-53. (IF=25.671)

6. Zhang H#, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B*. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nature Cell Biology.2020;22(1):18-25. (IF=28.824)

7. Liu Y#,  Fang Y#,  Chen X,  Wang Z,  Liang X,  Zhang T,  Liu M,  Zhou N,  Lv J,  Tang K,  Xie J,  Gao Y,  Cheng F,  Zhou Y,  Zhang Z,  Hu Y,  Zhang X,  Gao Q,  Zhang Y,  Huang B*. Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Science Immunology.2020;5(43):eaax7969. (IF=17.727, C100)

8.Liu Y#, Liang X#, Dong W, Lv J, Fiskesund R, Xie J, Jin X, Degao Chen, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Wang J, Hu Z, Cao X, Qin F, Huang B*. Tumor-repopulating cells transfer kynurenine to upregulate PD-1 expression in tumor-specific CD8+ T cells through AhR activation. Cancer Cell.2018;33:480-494. (IF=23.916)

9. Ma R#, Ji T#, Zhang H, Dong W, Chen X, Xu P, Chen D, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B*. A Pck1-directed glycogen 1 metabolic program regulates formation and maintenance of memory CD8+ T cells. Nature Cell Biology.2018;20:21-27. (IF=23.916)

10. Liu J#, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nature Materials.2012;11(8):734-41. (IF= 32.841, C100)