余佳，1978年生，研究員，博士生導(dǎo)師，北京協(xié)和醫(yī)學(xué)院長聘教授（首批）、RNA與干細(xì)胞生物學(xué)課題組組長，中國醫(yī)學(xué)科學(xué)院RNA與造血調(diào)控研究重點(diǎn)實(shí)驗(yàn)室主任，醫(yī)學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室PI。2006年7月畢業(yè)于中國醫(yī)學(xué)科學(xué)院/北京協(xié)和醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化與分子生物學(xué)系，理學(xué)博士。2006-2007年在美國伊利諾伊大學(xué)芝加哥分校工作(Post-doc)。2007-2009年在美國西北大學(xué)Feinberg醫(yī)學(xué)院工作(Post-doc)。2009年10月回國加入中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所生化系及醫(yī)學(xué)分子生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室。

RNA與干細(xì)胞生物學(xué)：造血干細(xì)胞起源、異質(zhì)性、譜系分化與生態(tài)的分子動力學(xué)圖譜；非編碼RNA加工與成熟的分子機(jī)制及其在干細(xì)胞分化與相關(guān)疾病中的作用機(jī)理；胚胎及成體干細(xì)胞功能的RNA調(diào)控機(jī)理；RNA代謝及調(diào)控的生理功能和轉(zhuǎn)化醫(yī)學(xué)應(yīng)用。

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2. Fang Wang#, Puwen Tan#, Pengcheng Zhang#, Yue Ren#, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Science Advcances. 2022 Jan 7;8(1):eabg5369. (IF=14.957)

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4. Yanni Ma#, Siqi Liu#, Jie Gao#, Chunyan Chen#, Xin Zhang#, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi*, Yong E Zhang*, Jia Yu*. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Developmental Cell. 2021 Feb 22;56(4):478-493.e11. (IF=13.417)

5. Yue Ren#, Yue Huo#, Weiqian Li#, Manman He, Siqi Liu, Jiabing Yang, Hongmei Zhao, Lingjie Xu, Yuehong Guo, Yanmin Si, Hualu Zhao, Shuan Rao, Jing Wang, Yanni Ma, Xiaoshuang Wang*, Jia Yu*, Fang Wang*. A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation. Genome Biology. 2021 Oct 14;22(1):290. (IF=17.906)

6. Xue Wang#, Changyun Ping#, Puwen Tan#, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*, Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. The EMBO Journal. 2021 Feb 15. 40(4):e104729. (IF=14.012)

7. Kai Li#, Jiayue Xu#, Yanyun Luo#, Dingfeng Zou, Ruiqin Han, Shunshun Zhong, Qing Zhao, Xinyu Mang , Mengzhen Li, Yanmin Si , Yan Lu, Pengyu Li, Cheng Jin, Zhipeng Wang, Fang Wang, Shiying Miao, Bo Wen, Linfang Wang, Yanni Ma*, Jia Yu*, Wei Song*. Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis. Genome Research. 2021 Jan. 31(1):13-26 (IF=9.438).

8. Jingnan Pi#, Wen Wang#, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang*, Jia Yu*. YTHDF1 promotes gastric carcinogenesis through controlling the translation of FZD7. Cancer Research. 2021 May 15. 81(10): 2651-2665. (IF=13.312)

9. Jie Zhou#, Jiayue Xu#, Lingling Zhang#, Siqi Liu#, Yanni Ma#, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019 Feb 7. 24(2): 285-298.e5. (IF=21.464 ,F1000)

10. Fang Wang#, Wei Song#, Hongmei Zhao#, Yanni Ma, Yuxia Li, Di Zhai, JingnanPi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu*. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. Cell Research. 2017 Mar. 27(3):416-439. (IF=46.297)