司書毅，1961年生，籍貫山東淄博，微生物藥物學家，醫藥生物技術研究所研究員，博士生導師。1982年獲中國藥科大學藥化專業學士學位。1989年、1999年獲中國協和醫科大學微生物藥學碩士學位、微生物與生化藥學博士學位。1995年赴日本北里研究所，1997年在東京理科大學綜合研究所，2005年公派赴日本RIKEN橫濱研究所，2007年赴美國Oregon國立大學等從事天然產物及蛋白質化學相關研究。

創新微生物藥物篩選與發現研究，抗感染藥物發現研究，抗代謝性疾病藥物發現研究

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1. H. Sun#, X. Li#, M. Chen, M#. Zhong, Y. Li, K. Wang, Y. Du, X. Zhen, R. Gao, Y. Wu, Y. Shi, L. Yu, Y. Che, Y. Li*, J-D. Jiang*, B. Hong*, S. Si*, Multi-omics-guided discovery of omicsynins produced by Streptomyces sp. 1647: pseudo-tetrapeptides active against influenza a viruses and coronavirus HCoV-229E, Engineering (2022), doi.org/10.1016/j.eng.2021.05.010, In press (IF=12.834)

2. Junxia Wang#, Minghua Chen#, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Xiujun Liu, Meilian Cai, Yuhan Qiu, Tianshu Zhang,Huimin Zhou, Wuli Zhao*, Shuyi Si* and Rongguang Shao*,The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells, Acta Pharm Sin B, 2022;12(1):210-227, (IF=14.911)

3. Yanni Xu#, Chang Liu# , Xiaowan Han#, Xiaojian Jia, Yongzhen Li, Chao Liu, Ni Li, Lunming Liu, Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang, Yu Du, Yang Xu, Jian-Dong Jiang*, Bin Hong *, Shuyi Si*. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e284-e298. (IF=8.331)

4. Xiaoli Zhao#, Shuai Lin, Huiyi Li, Shuyi Si*, Zhen Wang*, Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level, J Bone Miner Res. 2021 Mar; 36(3): 591–603. (IF=6.741)

5. Dongsheng Li#, Chao Liu#, Xinhai Jiang,Yuan Lin,Jing Zhang,Yan Li,Xuefu You,Wei Jiang,Minghua Chen*,Yanni Xu*,Shuyi Si*, Design, Synthesis, and Evaluation of Substituted 2-acylamide-1,3-benzo[d]zole Analogues as Agents against MDR- and XDR-MTB,European Journal of Medicinal Chemistry, 2020, 10.10    (IF= 6.514)

6. Minghua Chen#, Renzhong Wang#, Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan*, Feng Feng*, Shuyi Si*. Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Organic Letters, 2019, 21 (5), 1530-1533. (IF=6.555)

7. Wang W#, Liu C, Zhu N, Lin Y, Jiang J, Wang Y, Li Y, Si S. Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10.Acta Pharm Sin B. 2018 Sep;8(5):772-783.(IF=6.014)

8. Zhu N#, Lin Y#, Li D, Gao N, Liu C, You X, Jiang J, Jiang W*, Si S*, Identification of an anti-TB compound targeting the tyrosyl-tRNA synthetase. J Antimicrob Chemother. 2015 Aug. 70(8): 2287-94 (IF=5.313)

9. Yuan Lin#, Yan Li#, Yuanjun Zhu, Jing Zhang, Yongzhen Li, Xiao Liu, Wei Jiang, Shishan Yu, Xuefu You, Chunling Xiao, Bin Hong, Yanchang Wang,* Jiandong Jiang,* Shuyi Si,* "Identification of anti-tuberculosis agents that target ribosome subunit interaction using yeast two-hybrid system, PNAS, 2012, 109(43):17424-17429(IF=9.681)

10. Guo HF#, Shao HY, Yang ZY, Xue ST, Li X, Liu ZY, He XB, Jiang JD, Zhang YQ, Si SY*, Li ZR*, Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats, J Med Chem. 2010 Feb 25; 53(4):1819-29.(IF=5.207)