李平平，1978年生，籍貫吉林德惠，藥理學家，中國醫學科學院藥物研究所研究員，博士生導師。1996年考入中國藥科大學藥理專業，2001年獲得學士學位。2001年在中國協和醫科大學藥物研究所藥理專業攻讀博士學位，從事糖尿病研究。2006年進入美國加州大學圣迭戈分校進行博士后研究工作，主要研究慢性炎癥與肥胖和糖尿病。 2013年在美國加州大學圣迭戈分校升為助理教授。2015年在中國醫學科學院藥物研究所任研究員。

慢性炎癥、胰島素抵抗及胰島素分泌的分子機制；肥胖、脂肪肝、2型糖尿病及癌癥等代謝性疾病的發病機制、新藥靶發現與鑒定及新藥研發。

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1. Liu X#, Wang K#, Wang L, Kong L, Hou S, Wan Y, Ma C, Chen J, Xing X, Xing C, Jiang Q, Zhao Q, Cui B, Huang Z*, Li P*. Hepatocyte Ltb4r1 promotes NAFLD development in obesity. Hepatology. 2022 Aug 5. doi: 10.1002/hep.32708. (IF=17.298)

2. Ying L#, Wang L#, Guo K#, Hou Y#, Li N, Wang S, Liu X, Zhao Q, Zhou J, Zhao L, Niu J, Chen C, Song L, Hou S, Kong L, Li X, Ren J*, Li P*, Mohammadi M*, Huang Z*. Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects. Nat Commun. 2021 12(1):7256. (IF=14.919)

3. Li PP#,*, Liu SN#, Lu M#, Bandyopadhyay G, Oh D, Imamura T, Johnson, A.M.F., Sears D, Shen ZF, Cui B, Kong LJ, Hou SC, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM*. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 2016. 167(4):973-984.e12 (IF=30.41)

4. Li P#,*, Oh DY#, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (IF=30.357, C100)

5. Li, P. #, Spann, N.#, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C.*, Olefsky, J*.  NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids.  Cell 2013; 155, 200-214. (IF=33.116)

6. Baeza-Raja B#, Li PP#, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony, Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K*: p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (IF=9.737, F1000)

7. Li PP#, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM*: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011;147:815-826. (IF=32.403)

8.Lee YS#, Li PP#, Huh JY#, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB*: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (IF=8.286, C100, ESI).

9. Li PP#, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM*: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. (IF=5.476, C100)

10. Patsouris D#, Li PP#, Thapar D, Chapman J, Olefsky JM, Neels JG*: Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (IF=16.107, C100)