郭斐，1969年生，籍貫山東省，病毒學家，病原生物學研究所研究員，博士生導師，協和學者特聘教授。1987年考入山東大學微生物學專業，1991年獲得學士學位。1995-1999年在中國預防醫學院病毒學研究所分子病毒專業攻讀碩士-博士連讀學位，從事病毒載體疫苗研究。分別于1999年進入Johns Hopkins大學和2002年進入McGill大學進行博士后研究工作，主要研究病毒宿主相互作用。 2002年升為副研究員。2009年升為研究員。

重要病毒（艾滋病毒、流感病毒、猴痘病毒等）感染致病的關鍵科學問題：宿主胞內固有免疫感應及響應病毒感染及病毒的逃逸機制；新型抗病毒策略研究；病毒載體及病毒疫苗等。

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1. Fei Zhao#, Fengwen Xu#, Xiaoman Liu#, Yamei Hu, Liang Wei, Zhangling Fan, Liming Wang, Yu Huang, Shan Mei, Li Guo, Long Yang, Shan Cen, Jianwei Wang*, Chen Liang*, Fei Guo* SERINC5 restricts influenza virus infectivity. PLoS Pathogens 2022 accepted.

2. Jianyuan Zhao#, Jing Wang#, Xu Pang#, Zhenlong Liu, Quanjie Li, Dongrong Yi, Yongxin Zhang, Xiaomei Fang, Tao Zhang, Rui Zhou, Tao Zhang, Zhe Guo, Wancang Liu, Xiaoyu Li, Chen Liang, Tao Deng, Fei Guo*, Liyan Yu*, Shan Cen*An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA. Nat Commun. 2022 Apr 19;13(1):2079.

3. Xiaoman Liu#, Liang Wei#, Fengwen Xu, Fei Zhao, Yu Huang, Zhangling Fan, Shan Mei, Yamei Hu, Linxuan Zhai, Justin Guo, Aihua Zheng, Shan Cen*, Chen Liang*, Fei Guo* SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response. Sci Signal. 2022 Apr 12;15(729):eabg8744.

4. Yu Huang#, Fengwen Xu#, Shan Mei, Xiaoman Liu, Fei Zhao, Liang Wei, Zhangling Fan, Yamei Hu1, Liming Wang, Bin Ai, Shan Cen, Chen Liang*, Fei Guo* MxB inhibits long interspersed element type 1 retrotransposition. PLoS Genet. 2022 Feb 16;18(2):e1010034.

5. Xiaoman Liu#, Fengwen Xu#, Lili Ren#, Fei Zhao, Yu Huang, Liang Wei, Yingying Wang, Conghui Wang, Zhangling Fan, Shan Mei, Jingdong Song, Zhendong Zhao, Shan Cen, Chen Liang, Jianwei Wang*，Fei Guo* MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nat Commun. 2021 Jul 20;12(1):4427.

6. Hong Sun#, Yu Huang#, Shan Mei, Fengwen Xu, Xiaoman Liu, Fei Zhao, Lijuan Yin, Di Zhang, Liang Wei, Chao Wu, Shichao Ma, Jianwei Wang, Shan Cen, Chen Liang, Siqi Hu*, Fei Guo* A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA. Cell Rep. 2021 Jan 5;34(1):108586

7. Lijuan Yin#, Fei Zhao#, Hong Sun#, Zhen Wang, Yu Huang, Weijun Zhu, Fengwen Xu, Shan Mei, Xiaoman Liu, Di Zhang, Liang Wei, Shan Cen, Siqi Hu*, Chen Liang*, Fei Guo* CRISPR-Cas13a Inhibits HIV-1 Infection. Mol Ther Nucleic Acids. 2020 Jun 1;21:147-155.

8. Fengwen Xu#, Fei Zhao#, Xiaoxiao Zhao, Di Zhang, Xiaoman Liu, Siqi Hu, Shan Mei, Zhangling Fan, Yu Huang, Hong Sun, Liang Wei, Chao Wu, Quanjie Li, Jianwei Wang, Shan Cen, Chen Liang, Fei Guo* Pro-515 of the Dynamin-Like GTPase MxB Contributes to HIV-1 Inhibition by Regulating MxB Oligomerization and Binding to HIV-1 Capsid. J Biol Chem. 2020 May 8;295(19):6447-6456.

9. Siqi Hu#, Hong Sun#, Lijuan Yin#, Jian Li, Shan Mei, Fengwen Xu, Chao Wu, Xiaoman Liu, Fei Zhao, Di Zhang, Yu Huang, Lili Ren, Shan Cen, Jianwei Wang*, Chen Liang*, Fei Guo* PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing. Sci Signal. 2019 Nov 26;12(609).

10. Siqi Hu#, Jian Li#, Fengwen Xu, Shan Mei, Yann Le Duff, Lijuan Yin, Xiaojing Pang, Shan Cen, Qi Jin*, Chen Liang*, Fei Guo* SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.  PLoS Genet. 2015 Jul 2;11(7):e1005367.